In vitro Metabolism of Genistein and Tangeretin by Human and Murine Cytochrome P450s
نویسندگان
چکیده
منابع مشابه
Flunitrazepam metabolism by cytochrome P450S 2C19 and 3A4.
We have identified CYP2C19 and CYP3A4 as the principal cytochrome P450s involved in the metabolism of flunitrazepam to its major metabolites desmethylflunitrazepam and 3-hydroxyflunitrazepam. Human CYP2C19 and CYP3A4 mediated the formation of desmethylflunitrazepam with Km values of 11.1 and 108 microM, respectively, and 3-hydroxyflunitrazepam with Km values of 642 and 34.0 microM, respectively...
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ژورنال
عنوان ژورنال: Pharmacology & Toxicology
سال: 2003
ISSN: 0901-9928
DOI: 10.1034/j.1600-0773.2003.930102.x